Excellent post Spino. I have Gleason 9, stage 3C , seminal invasion PC and I had 6 months of ADT before RP, in a clinical trial at UCLA. My surgeon and medical team, advised me that the ADT before surgery was not presently the standard of care, but it would make the cancer softer and facilitate cutting out all of the cancer and perhaps get a cure of my aggressive, CR , advanced, PC. (a cure is defined as cancer free for 5 years). Getting ADT before RP was possible for me due to the clinical trial. I was also on ADT and Erleada for 6 months post RP. There are many ways to skin a cat with this damn PC but I think that the most important thing is having excellent and caring and very experienced medical practitioners, at an excellent, modern facility, and being a good listener and doing your homework. I think that no matter how much homework you do, and how smart you are, your knowledge is still that of a layman and not equal or superior to your excellent medical team. I have a pet scan and blood test scheduled in the next 2 weeks and hopeful for a good report