Hello Ray, in my first week of new treatment andwill let you know of any improovements.. The hardest part is the 80 oz water, quite a lot for take in each day but I will try. Notice slight imrovement already in balance. It is a rigorous protocol but willing to try anything at this point. Idiopathic polyneuropathy is the most complex, I believe, because diabetes is easier to treat than not knowing the origin of the disorder. Mine started after subdural hematoma in 2016. Exercise is key to managing the progression of the weakness in the legs and feet. Check ingredients in 525 and try to concentrate on those . Therapeutic dosing seems to be the key. RDAs are set too low, in my opinion, only to prevent certain diseases, so perhaps the Protocol is the answer, vitamins in therapeutic doses. We shall see......