Yes I had to discontinue after my second treatment. My body just couldn’t handle it. I think had I not developed an obstruction and ultimately another abscess, they may have considered changing dosage or switched to something else, but my oncologist said any benefit was far outweighed by the risk. Chemo was given as an option and I chose to try it because I wanted that extra layer of protection. I’ve been almost four years with NED. Praying that my upcoming colonoscopy will still be good. I have ulcerative colitis so I’m afraid a higher risk of cancer so thankfully have had annual colonoscopies for the last 10 years, and this will be my second one in 12 months.