A while back I posted that I would be trying low-dose naltrexone and would report the results. Here is an update after one month of LDN. I began taking 1.1mg of LDN in addition to my regular dose of prednisone. I had just tapered slowly to 12 1/2mg, taking 5mg at 2 AM. After a week I noticed no effect of the LDN and began taking 2.2mg of it. After another week, still no perceived effect, so went to 4.5mg, which was one tablet of LDN. After trying various time and dose combinations, I decided to try to taper the prednisone to 10mg. I took the prednisone, one 10mg tablet, at noon, and 4.5mg LDN at 11:30PM. For the first two days I woke with a feeling of mild euphoria, but still could feel the PMR in my left bicep and shoulder. On the next day there was no pain or stiffness, and for the last two days I have felt like there was no PMR at all. I plan to keep to this regimen for a week and then try to continue the prednisone taper, slowly. It is early days and who knows if this success will hold. My hope is that the LDN will help me taper more easily than I could without it. My second hope is that I can eventually stay on a maintenance dose of LDN instead of prednisone. Whereas prednisone does the job on PMR, it suppresses the immune system and comes with negative side effects. LDN, on the other hand, works by bolstering the immune system and should have some power to bypass or mitigate disease. I have done a great deal of reading about LDN and recommend the several books and many pages of web material. So far, LDN looks promising, but we have a mystery disease and the future is unclear.