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Monitoring PSA post Prostatectomy when should I be concerned?

Posted by jmp6477 @jmp6477, Mar 1, 2023

Prostatectomy in December of 2016. PSA in May 2021, .017. August 2022, .024. February 2023, .034. Should I be concerned with PSA doubling in 2 years? I do have appointment with my urologist next week.

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greglynch7 | @greglynch7 | Mar 24, 2023
In reply to @rxharleydude "Just curious, are you currently on any type of treatment going forward, such as a ADT..." + (show)
@rxharleydude

Just curious, are you currently on any type of treatment going forward, such as a ADT or an antiandrogen med, etc?

I had my prostate removed about 11 years ago, but have been on Lupron pretty much the whole time and then Abiraterone(Zytiga) added a couple of years ago. I was doing pretty well and tolerating everything until about 6 months ago. Currently my PSA’s have been rising. PSMA Testing shows that the cancer has metastasized into my bones so will be seeing my oncologist next week to discuss options going forward. Looking at chemo, Xofigo, Pluvicto to name a few. Things are getting a bit scary for me now.

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Our stories are very similar, see previous -long !- post. last week.
20 years, so 10 ahead of you, and have had many treatments with pluvicto next and a few that have fallen out of favor or protocol changes.
Meaning, there are always changes and new opportunities- as few and as far between as it seems at times.
So stay very positive as this train isn’t stopping for us but keep looking for new “brakes”. AND above all keep advocating for your self with whatever reputable sources you are researching. Cheers

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perrychristopher | @perrychristopher | Mar 24, 2023
In reply to @jmp6477 "Had my appointment today and my urologist was not concerned at all. She said they wouldn't..." + (show)
@jmp6477

Had my appointment today and my urologist was not concerned at all. She said they wouldn't be concerned until PSA reached 0.2. Very good news indeed!

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Yes Sir. Great News.

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swdg | @swdg | Mar 24, 2023

In case you did not see this paper in one of the threads that Colleen mentioned: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586061/

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philipsnowdon | @philipsnowdon | Mar 24, 2023

Hello, all helpful comments! I recently had my Radical Prostatectomy on 10/25/23. Thankfully, it went very well and my prognosis for the future is very optimistic. My PSA has been staying consistent at

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johnwang | @johnwang | Mar 25, 2023

Did prostatectomy in 2019, my PSA went up from 0.008 to 0.030. My question is: 1. Could a growing PSA mean a grow back of normal prostate tissues? 2. Is it necessary to do some sort of test to determine if there is any cancer cell before any further treatment becomes necessary?

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2 replies
healthyhappy | @healthyhappy | Mar 25, 2023

Regardless of what your slowly increasing PSA portends, rest assured that you will have many treatment options if treatment is recommended but do seek out consultations with experts at centers of excellence like Mayo or perhaps The Brady Urological Institute at Hopkins. My PSA following prostatectomy in 2016 wobbled for many months but eventually settled down to near zero. The experts I spoke with during that time were quite encouraging about my long-term quality and duration of life if I opted for additional treatment (I did not). One of them said that PCa recurrence with the low PSA levels you describe (similar to mine) has an excellent prognosis with improved treatment options constantly emerging.

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gkm | @gkm | Mar 26, 2023
In reply to @johnwang "Did prostatectomy in 2019, my PSA went up from 0.008 to 0.030. My question is: 1...." + (show)
@johnwang

Did prostatectomy in 2019, my PSA went up from 0.008 to 0.030. My question is: 1. Could a growing PSA mean a grow back of normal prostate tissues? 2. Is it necessary to do some sort of test to determine if there is any cancer cell before any further treatment becomes necessary?

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More likely some cancerous cells remain after the RP but at this stage your PSA is still low. Continue with 1/4ly PSA's and monitor the doubling time.

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gkm | @gkm | Mar 26, 2023
In reply to @johnwang "Did prostatectomy in 2019, my PSA went up from 0.008 to 0.030. My question is: 1...." + (show)
@johnwang

Did prostatectomy in 2019, my PSA went up from 0.008 to 0.030. My question is: 1. Could a growing PSA mean a grow back of normal prostate tissues? 2. Is it necessary to do some sort of test to determine if there is any cancer cell before any further treatment becomes necessary?

Jump to this post

Go to "Need Radiation Guidance" topic and "@web265's" reply

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