When I got down to 2mg last fall I had more stiffness at the back of my thighs and pain in both wrists. I take Tylenol ES when needed. It is manageable and I didn’t want to increase the prednisone. About 6 wks ago I went down to 1.5 mg and no new issues so now I’m going to reduce to 1 mg. I have been on Prednisone for 2 yrs.