Lupron…1 dose of 45 mg. When will the affects wear off?

I am on Lupron for 2 years and I'm 1 year in. I was told it takes 6 mos for Testosterone to come back . In your case you could hope for a little less time to reach normal. The hot flashes and fatique is anyone's guess.
Good luck

In Feb as I was debating taking my 3rd dose of Lupron in 18 months my urologist told me the side effects will probably never completely wear off, especially the joint pain. In June I'll take my fourth and final dose!

I was on Lupron for 25 months through about May of 2019 and my testosterone has never come back. It remains at about 15 and most likely will for the rest of my life. As a result I have very little energy and am not a fan of Lupron.

I have heard that the restart of testicular activity is iffy. I think it might be an age thing. At 75 I should prepare for that.
I am beginning to have doubts about lupron as well. Twice now I have had reactions to the injection. It starts with chills shivering and teeth chattering in the middle of the night (after injectiion) and then nausea and dis orientation through the next day.
Sorry to hear your difficulties. I hope your PSA is low and your prognosis is in your favor.

T
Yes, there is a side benefit to having low testosterone and that is that prostate cancer is less likely to reoccur. However, I'd like to have more energy than I have.

My husband had the same effects as spryguy! Chills/chattering teeth etc, needless to say the doctor stopped his treatments after 5, …. Now he is on Xtandi -4 capsules daily! Just started then 2 weeks ago

I actually had Eligard, not Luprin, back in December, plus 3 weeks of Casodex to counteract the expected testosterone bounce. The drugs are essentially the same, but Eligard is a newer version, so the technician giving me the shot explained. And the side effects were negligible to me, so perhaps it's a better option. No night sweats, no muscle loss, and minor weight gain. A little fatigue and libido loss were noticed, but neither were as debilitating as some of the horror stories I've read about.

My RO told me just the other day that, being in the "intermediate unfavorable" category (PSA under 10, Gleason 6 and 7 but a lot of them) and that I did Brachytherapy as well as LDR (15 of 23 down so far), I would not need another injection at this time. YAY!

He also noted that my testosterone should begin to recover in about 3 months, and another PSA test will be done in July or so. Also, since the prostate was not removed, a PSA of about .5 is to be expected, not a 0.05 if RP had been performed. Hey, the prostate is still there, and it has to do something. Still well within limits, but I think he was giving me a heads-up so I don't panic when I get the results back this summer.

Hope you are doing well and that the recovery goes smoothly. That's all any of us can hope for, I suppose.