I got relief within a day or so. I use it mostly in the morning when I wake up, I have a post nasal flow for the next hour. There are many conditions that can trigger a flow, and I went to my ENT to get some relief. He gave me this, because it acts quickly, and you can take it as needed, unlike most of the other nose sprays. Did you see my post about chewing red bell pepper to dissolve the mucus at the back of the throat?