I just finished 12 cycles of Folferinox after distal pancreatectomy, and my digestive system has changed. I experienced heartburn, GERD, and bloating after each treatment, and I have to eat smaller portions of meals (6 small meals rather than 3 large meals). I regularly take Omeprazole (oncologist prescribed this) plus OTC antacids, simethicone, and Beano. It usually works. I hope this information is a little helpful. Best wishes.