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Polymyalgia Rheumatica (PMR) | Last Active: 2 days ago | Replies (226)
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Today is day two after my first dose of MTX. All I got in side affects is 12 hours with lots of rear end gas. Today I am fine. MTX takes 2 to 3 months to get into your system and start to work. I am also weaning off Pred. Was on 20mg, dropping 5mg a week under Rheumy supervision, and will continue at 7.5mg daily until my next dr. visit at which time she will increase my MTX dose to 25mg and hopefully drop pred. completely. Best part of MTX....you can 'up and quit' at any time with no side effects, no weaning.
Those having trouble with MTX, did you start at low dose and then increase 3 months later to the full dose?
Best of luck to all in defeating your PMR.
Replies to "Today is day two after my first dose of MTX. All I got in side affects..."
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I took MTX for 4 months gradually increasing dose. Switched to injectable to hopefully have less severe side effects but it did not help. Rheumatologist said I should quit and I did. Your statement about you can quit any time is true but I suffered a huge PMR pain flare when I quit. It took a few months to get it under control again. I did get to a lower dose (10 mg) of prednisone but was it worth it? I have been able to reduce very slowly after going back up with the flare and am now down to 13 mg.