Yes! I take hydrocodone 10/325 and have for 20 years. I've gone from every 6 hours to 7 hours. There are times I need them every 6 or 4 hours and I always have to push my appointment out a couple weeks because I have too many left. Even when my script says 4 times a day, I only had 3 because I don't take them after 6, I'm usually in the bed watching TV and fall asleep and I don't need them when I'm sleeping. But yes, I've always said if you take them for what they are intended, you don't worry about abusing them. If I was taking them to get a buzz, after 20 years I'd need 3 at a time instead of 3 a day. I don't drink so I don't have that issue.