My experience with LDN and PMR is some what unique in that I tried LDN out of despiration because my rheumy was unable to diagnose me. I asked for the script after I read about it and was in two types of pain. The LDN helped (2 days!) my non-moving pain and left me with just the using my muscles pain. I was still on the LDN when I switched docs to one that recognised the PMR and started me on 20mg of methylprenisolone. Once again, after 2 days, no pain. Now pain free and I started to get my life back. This was interrupted, however, by my husband having a major heart attack. Essentially, he died and they wouldn't let him go. Somehow, he did great (the docs called him the miracle man) but I had to be too active. Much more than what was good for me considering my status. My advice to everyone, is take it slowly. Yes, you feel so much better, but just because you can doesn't mean you should. You are probably deconditioned. Make haste slowly. It will go better.