I have been on the Big 3 for 18 months. I started with a 3 day a week regimen, but increased to daily dosing along with Arikayce after 10 months with no sputum conversion. I had a bit of stomach upset after taking the Azithromycin and Ethambutol, but that dissipated after the first month. The only other side effect I've had is intermittent hoarseness from Arikayce.