I did an Enbrel trial back when it first was available but it had no effect. My PCP sort of predicted this as the AS had run its course; the inflammation was history; and I was left with fused joints and less pain. I got off the NSAID & Oxy and have taken Tylenol ever since. I don’t drink any alcohol so that made the transition to Prednisone tapering 3 years ago easier. Suspect others may have different experiences with biologics. I suspect they would have made a huge difference if available in the 70’s.