I take it every night & my doctor supports this over prescription sleeping pills, pain pills or anti depressants. When I don't sleep, the neuropathy pain gets worse, my stress level goes up & starts a cycle that can last for days. She feels getting 2-3 hours of fitful sleep will negatively impact my health & quality of life more than the benadryl. All drugs have side effects. It's a trade off I'm willing to take over unbearable pain & exhaustion. I still have pain during the day, but it is manageable when I sleep. Sleep heals.