I am approaching six years on Anastrozole. I also take Zometa infusions every six months. Joint has been bad this past year. In order to keep going I have to take ibuprofen which is dangerous due to kidney compromise. The last doctor offered 2 choices: quit Anastrozole or switch to another aromatose inhibitor. I opted for a 3rd choice: continue Anastrozole and ibuprofen. From all I have read and heard, Anastrozole is better than the other choices in preventing a recurrence. Also the others drugs have many of the same side effects. I have seen 6 different doctors (same office) in the past 6 years so no continuity in treatment and I feel like I am flying blind.