Though it's likely this topic has been covered before, I am new to this site.
A brief history: seven years ago I was prescribed 150mg Effexor ER in order to get out of the protracted withdrawal from Lexapro which had stopped working after six years. Effexor worked very well until last summer, when it too started to fail; by last fall complete failure, and my doc tried increasing the dose (no effect) and then Abilify (a two day nightmare). There remained no choice but to gradually taper the dose by 32.5mg reductions. I am now at that lowest dose and due to go down to zero in a week. I know I'm not breaking new ground in saying how painful this has been, along with the corrosive effect upon one's enthusiasm, and I anticipate the same when I'm completely off of it. Among the few who experience what I believe is now called antidepressant tachyphylaxis. If anyone has had the same and has found anything that provides even slight relief, I would appreciate hearing about it.