Hello,
I'm sorry for what you are going. I have Severe Treatment Resistant Major Depression. I've been on all but one of meds you mentioned. I have tried ECT, TMS, Spravato and Ketamine infusion. The only one of those that helped was ketamine infusion. It was a game changer!! I didn't realize how depressed I really was until I was on the other side. The effect of the first infusion lasted close to two weeks. It was amazing! I was hopeful, getting out of bed and getting things done..I had zero suicidal ideation. Unfortunately, the clinic stopped doing it by infusion and would only do it by injection. It just didn't have the same effect at all. I'm on SSDI for my depression and anxiety, so I only work part-time. I can't afford to pay out of pocket at another clinic that does the infusion. TMS didn't do a single thing for me, but for others it has helped. My PCP has suggested that because of weight, the medications aren't working. He said that the drugs are tested on people who are average weight and I'm morbidly obese. I'm working towards bariactric surgery this summer, so I'm hoping that he is right. I know I'll definitely feel better losing weight but I don't know if it will be the "cure". Only time will tell. What he says makes sense, though, that my weight impacts the medication working properly. I hope you will try ketamine infusion, I know that everyone is different and responds differently, but it certainly was amazing for me.