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Low Dose Naltrexone and Prednisone for PMR?

Polymyalgia Rheumatica (PMR) | Last Active: Apr 28 9:26am | Replies (75)
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@pkalkstein

I will post my experiences, probably starting next week. Meanwhile, have you tried taking part of your dose at 2 AM? That cut my pain to almost nothing. Apparently doing that heads off the cytokine rush that happens from 4-4:30, or so I read.

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Replies to "I will post my experiences, probably starting next week. Meanwhile, have you tried taking part of..."
cambrose | @cambrose | Mar 12, 2023

This was very helpful. I had tapered down to a low dose 2.5mg prednisone for six months with some stiffness/achiness that was manageable. I went up to 3.75 when it seemed to increase/worsen this winter. After reading your comments I have been that dose at 3-4 am and noticed much improvement. My mornings are much better with this timing.

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