Good morning! Have you narrowed down your search?

There are quite a few conversions with members about lodging in Rochester that might be helpful for you. The closer to the clinic, the prices will be higher…paying for convenience.
There are hotels further away that offer shuttles to and from the clinic. Parking is at a premium!
https://connect.mayoclinic.org/discussion/solo-in-rochester/
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https://connect.mayoclinic.org/discussion/what-are-your-accommodation-recommendations-when-coming-to-mayo/?pg=1#comment-49115
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https://connect.mayoclinic.org/discussion/where-to-stay-1st-visit/
I’m a regular at Mayo, making frequent visits. My husband and I always stay at the Marriott Residence Inn on Center street. It’s 2 blocks from the campus and directly connected to the clinic with the subway (walkway). Full sized refrigerator, nice kitchen with either cook top or full oven depending on the room. Dated rooms, but clean and the staff is great.

Wherever you choose to stay, call directly and ask for the Mayo discount! Is this your first time in Rochester? (Super easy to get to the clinic)