Hello Bethf, while I know it is tough to find out that the tumor marker tests are going up, it is great news that you are feeling well and the scans are stable so far. In regards to your two options, my understanding is that most clinical trials do require "measurable disease" in order to qualify. Specifically, they need to see at least one centimeter of tumor somewhere in the body that is confirmed either with a biopsy or PET scan showing that it is in fact cancer. You mention in your post that your scans do not show evidence of cancer right now. Please double check the requirements to get on the immunotherapy trial to be sure there is no requirement for measurable disease. If there is such a requirement (which is common), your choices at the moment would only be chemo or waiting until measurable disease appears on the scan. It's difficult to say what is the best option, as you do not want to interrupt the good quality of life you are having now. I would talk to your oncologist and see what he/she recommends. One medium option I can think of is to perhaps try chemotherapy for a month or two and see if your tumor marker numbers go down. If they do, you know it is working and you can continue for some time if you feel your quality of life is still ok while on chemo. If not, you can then attempt to get on the trial. Generally, clinical trials that are not specifically geared to a specific mutation/fusion that your tumor has are used after the standard chemo options are no longer working or tolerable. The great thing right now for you is that you are feeling great and have some time to make a very well researched and planned out treatment decision. This is a huge blessing.