I've recently tapered off Cymbalta after taking it for 18 years. It served me well for about 16 of those 18 years, but it was time for a change, which can happen.

Just take it at the same time every day and remember it has a short half-life, which can cause withdrawal symptoms (brain zaps, headaches, nausea, etc.) if you miss a dose or lose it before you absorb it (stomach flu...).

And if you do decide to stop taking it, taper off gradually under doctor's supervision, particularly when going from the lowest dose to nothing.