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Xtandi and Lupron: Possible drug interaction with spironolactone?
Prostate Cancer | Last Active: Feb 28, 2023 | Replies (5)Comment receiving replies
Hi @ronnieh, this is a new one for me. But I have some members who might be able to offer ideas or experiences about prostate treatments and possible interactions with heart meds, like @markheuer @dirtdancer @dakotarunner @hbp who have or are taking enzalutamide (Xtandi). And @ruste is taking Plavix along with Xtandi for heart issues and may have thoughts to share.
Heart issues can be a concern with some treatment options. You may ask about a cardio-oncology specialist or department.
Mayo Clinic offers a program to address heart problems associated with cancer treatment called cardio-oncology or for people who have a pre-existing heart condition when diagnosed with cancer. The Cardio-Oncology Clinic (https://www.mayoclinic.org/departments-centers/cardio-oncology-clinic/overview/ovc-20442193) evaluates people prior to cancer treatment and patients who have experienced side effects due their treatment, and can help evaluate treatment when you have both cancer and heart conditions.
Another option is to discuss with on oncology pharmacist.
Do you have access to a similar cardio-oncology program or a knowledgeable pharmacist?
Replies to "Hi @ronnieh, this is a new one for me. But I have some members who might..."
Yes, I have asked this same question to my urologist, oncologist, and
pharmacist. No definitive answer, but since spironolactone has caused a
rise in psa and progression of cancer in a couple of PC patients that were
taking abiraterone there is some concern. Spironolactone is considered a
aldosterone modulator rather than an aldosterone agonist, and in some cases
can actually cause testosterone to rise in a low T environment, which can
affect PSA levels.
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Before I was treated for prostate cancer, my cancer doctors required that I be cleared by my cardiologist and family doctor. I believe that the pet scan and chest scan and bone scan and full body scans were done before they required the clearance from the cardiologist. After all of this I was placed on ADT and Ereada for 13 months with a RP midway through the treatment. At this time I am being monitored and blood tested every 3 months and my PSA was last .01