My side effects started with immediate face flushing and tingling around my mouth,cheekbones and the corner of my eyes. These lasted for about 10 days. The second and third doses, I had the same reaction but they lasted less time. I just did not like the way it made me feel and the fact that this drug had not been out that long really bothered me. My endocrinologist took the initiative and contacted the manufacturer and they agreed that this may not be a good match for me. The Reclast has been around a while,plus it frees you up to live your life with only once a year. I guess I won’t know the impact until this fall when we do a new bone scan.