Thank you for this. I, too, have lifelong constipation which is now mostly managed successfully with 600-900 mg Magnesium Citrate daily and a probiotic (either Inner-Eco or Zenwise, which I learned about from a member on this site). I have a known "severely" tortuous colon and imagine my evacuation rate is very slow, though I've never done the smart pill. I have two questions for you. One, gluten. I confess I have never done the full gluten-free diet because so many people told me it was a fad and that unless you have celiac it's not a likely culprit. Your report makes me wonder if it's worth trying. Two, have you suffered back pain/joint instability? I feel my hypermobile joints - and in particular my Sacroiliac Joint dysfunction - is directly linked to my large/stressed out/tortuous colon. My GI doc doesn't seem to think they'd be related, but I wonder, anecdotally if others have this experience. My 21 year old daughter seems to have a similar set of symptoms (constipation/SI dysfunction). We do not have IBS. Thanks!