After taking cholestyramine and using Pepto Bismol for a long time, the cholestyramine stopped working, along with the Imodium I took off and on. Then I developed A-fib which meant I could no longer take Pepto Bismol because it contains aspirin. Finally, after checking online, I eliminated lactose, gluten, nuts, uncooked fruits and vegetables, and so forth from my diet. It changed my life! I'm keeping a food diary now to learn how to eat. Why didn't my gastroenterologist tell me about this?!