Hi Windyshores,

No, you don't have to be careful taking them out. These specialized earplugs have a tiny ceramic baffle, or filter inside, which slowly lets the barometric pressure in, which will hopefully alleviate/temporarily eliminate migraines. Of course, migraines are a neurological disease and tend to run in families, and are not curable. There is an app at the Google Play store which goes with these earplugs. WeatherX. It will let you know an hour ahead of time when to expect the pressure changes. It's rather intuitive and has a graph, and it collects data from several days, so you can view the different trends. Truthfully, they have helped to either eliminate temporarily the migraines, or at least lessen the severity. I hope this helps you, good luck!