Hi there-
Yes, you are correct: if the spleen can be saved, long term your wife will be able to fight off infections easier, however, most surgeon's will remove it because it has such a rich blood source and is connected to the pancreas. My suggestion would be to share that concern with your surgeon. When I asked my surgeon about this same concern, he explained that he would try to save it, however, it's a very tricky and complicated surgery. My surgery started as laparoscopic but was converted to an open surgery. I would ask about drainage tubes, of the cancer has metastasized, what grade/type of tumor(s) they found, length of hospital stay, probable outcomes, and what vaccinations she will need for life if the spleen is removed. Due to my spleen being removed, I need numerous vaccines at varying intervals for the rest of my life. I would inquire about that also. I would be very interested to hear the outcome of your wife's surgery. I currently have a lesion on my liver that is small, however, my oncologist is watching it closely. I wish you and your wife peace as you head into the unknown. It can be scary but know that you have a huge support network here at Mayo Connect. If I can help further, please let me know.

Warmest Regards,
Sherry