Lupron Depot: Weakness and instability side effects

I had the initial Lupron shot a month and half ago. Two weeks ago I had the second shot as a start of the three month series. No instability at all. No fatigue either, only flashes which were taken care of by a shot. I do three days in the gym and walk daily without any problem at all. We are all different but your case needs review by a competent doctor. Good luck.

I am on my second round of Lupron (injection every six months). It took months before the general weakness got better. I still have some days of general fatigue and I’m never up to pre Lupron energy levels. However, I feel much more normal after about seven months. I try to walk and exercise on a regular basis and play with my three year old grandson every day. Being 68, I have age related issues along with the Lupron. Just keep your mind and body active and stay positive.

I was told I was getting Lupron for my ADT in December, but my HCP changed it to Eligard at the last minute. The NP said that the Eligard was a newer version, but the same medically as the Lupron (which it appears to be on researching). I also had a 3-week regimen of Casodex once a day to combat the testosterone spike that often occurs with ADT drugs. A drug to drop your testosterone initially increases it, go figure!

Anyhow, I had a little bit of fatigue and some walking anomalies to start, but they went away within a month. Could have been the Casodex or adjusting to the loss of testosterone, but it did subside fairly quickly. I work at a job that has me on my feet all day and I average about 6 miles per day walking as a result, so that may have also contributed to my recovery from walking instability.

My only problem is that my shot was about a week before Christmas, so I had a relatively "dry" holiday season. Tried a glass of wine with Christmas dinner, but it made me pretty loopy fairly fast. Something that normally does not happen to me. So, no booze, non-alcoholic sparkling wine for NYE, and all is well.

Two months out from the shot, and aside from the libido differences, I look, feel and act just like I did before.

After taking Lupron for about 12 - 15 months, I noticed substantial weakness in my legs and suggested the loop fun treatment be stopped but my urologist insisted I take it for 2 years. I think I am an exception but I am permanently left with very little testosterone (15) and thus very little energy and some instability even though I haven't taken Lupron for several years.

Oops I didn't mean " Loop fun" but meant "Lupron."

I'm newly diagnosed at 54 years old. I'm getting my first Lupron shot Thursday. I'll be walking around the block regularly based on what's being said here. I didn't know instability was a side effect. I'm not the kind of guy to sit around, so I will push myself even if I feel fatigued.

I think my instability comes from weakness in my legs and I regularly exercise hard to strengthen them. One thing I do is sit on a chair and stand up and sit down as many times as I can in 30 seconds. I do that times plus do other legs strengthening exercises. Good luck.

I do the sit down and stand up exercise three times for 30 seconds each.

I found that pushing yourself when fatigued is the only way not to feel fatigued. That may not make sense but that helped me!

I did 18 months of ADT. The list of possible side affects is "endless."

Think of the Bell curve, most of us will fall within the norm, some will experience more, others less.

For me, it was:
Hot flashes
Mild joint and muscle soreness
Mild fatigue
Genitalia shrinkage.

I pretty much maintained my normal diet and exercise, used the elliptical, swam, lifted weights, went skiing, hiked in the mountains, walked my dog, played basketball....

What you are experiencing may be linked to your ADT, talk with your medical team, consult a specialist if an option.

Kevin