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Transitioning from a PPI to an H2 blocker

Digestive Health | Last Active: Dec 14 8:01am | Replies (34)
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@gird66

Great, to know that tranisitioning to H2 is possible. Probably going to use the weaning off approach that stickyrice mentions. The PPIs were apparently never studied for long term use and after what happended with Zantac its buyer beware. Also recent mendium term studies show an increased risk of Gastric Cancer, a chance I am not willing to take.

" Long-term use of PPIs was still associated with an increased GC (Gastric cancer) risk in subjects even after HP eradication therapy"
"The long-term use of proton pump inhibitors (PPIs), a class of drugs commonly used to treat acid reflux, is linked to a more than doubling in the risk of developing stomach cancer."
"After a median follow-up of 5.0 years, the use of PPIs was associated with a 45% increased risk of gastric cancer compared with the use of H2RAs"
You can google the quotes and see the links and articles

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Replies to "Great, to know that tranisitioning to H2 is possible. Probably going to use the weaning off..."
mrsbeard26 | @mrsbeard26 | Feb 18, 2023

Exactly. I’m terrified I’ll have it. I’m on keto also

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Colleen Young, Connect Director | @colleenyoung | Feb 20, 2023

Welcome, @gird66. I noticed that you wish to post links to research articles with your message. You will be able to add URLs to your posts in a few days. There is a brief period where new members can't post links. We do this to deter spammers and keep the community safe. Clearly the links you wanted to post are not spam. Allow me to post them for you:
- Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study https://gut.bmj.com/content/67/1/28
- Long-term use of PPIs linked to stomach cancer https://www.europeanpharmaceuticalreview.com/news/68840/ppis-stomach-cancer/
- Proton pump inhibitors and risk of gastric cancer: population-based cohort study https://gut.bmj.com/content/71/1/16

Have you talked to your doctor about weaning off PPIs?

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