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Letrozole and TMJ?

Breast Cancer | Last Active: May 13 8:34am | Replies (17)

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@bloncape

I’m sorry to hear about your problems with TMJ while taking Letrozole. In 2020, after taking 1/2 dose of anastrozole for one month, I began to take a full dose. I had MANY side effects, one of which was TMJ. My quality of life was very poor. Being new to this medicine, I was not aware that an aromatase inhibitor could cause TMJ. My former oncologist did not acknowledge TMJ or most of my other complaints as being caused by anastrozole. I stopped taking the drug after 6 weeks at full dose. Nearly all of the side effects, including TMJ, went away after some time.

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Replies to "I’m sorry to hear about your problems with TMJ while taking Letrozole. In 2020, after taking..."

Hi Bloncape,
I am experiencing the same reaction from my Mayo oncologist. He said TMJ is not a SE. I took 2 AIs and Tamoxifen over the last 10 months. Both of the first 2 times I stopped, the headaches went away. I suspect they will now too as I'm stopping the drug. It's very disappointing.

I, too, went through a serious recurrence of TMJ after being on Letrozole for about 3-4 months. At 6 months now — serious anxiety, insomnia, heart palpitations, and easily bruised skin. I feel fragile physically and emotionally…is this really worth it, I wonder..? Before BC, I was a reasonably fit and healthy 60 year old. Some days now I feel like I’m 80 🙁