The only person I know personally who got ovarian cancer and died in her early 50s from it, drank and smoked a lot. I also know smokers who never get cancer but as they age, the negative effects of the smoking, chemicals and constantly depriving their bodies of oxygen, are readily apparent.

HRT can cause breast or ovarian cancer (other “female cancers”).
https://www.cancerresearchuk.org/about-cancer/causes-of-cancer/hormones-and-cancer/does-hormone-replacement-therapy-increase-cancer-risk
Smoking destroys the body and although too many ppl only associate smoking with lung cancer, smoking can cause pretty much any type of cancer along with a plethora of other negative health conditions.
https://www.cdc.gov/tobacco/campaign/tips/diseases/cancer.html
https://www.healthline.com/health/understanding-breast-cancer/can-smoking-cause-breast-cancer#tobacco
If a woman smokes and takes HRT, common sense says that woman’s smoking habit will increase her risk of getting breast cancer.