I got a shot of Lupron prior to PBT 4 years ago at PHX Mayo, “6 months” shot lasted about 10 months. Gained weight, lost strength, hot flashes. PSA started at 11 came down to 0.2, and it stayed there ever since. Lupron was certainly manageable for me, but I know for others not so much. The folks at Mayo were great, I trust their judgment.

May help to give a summary of your clinical history. Generally, hormone therapy is given in conjunction with radiation therapy for several reasons:

To deal with micro-metastatic disease that is not treated with radiation and the treatment fields.
It does have a symbiotic affect

The duration can vary, for low and moderate risk, may be six months. For high risk, may be 18 months.

The side affects are well known though may vary by individual, overall health, physical condition and whether or not you are "active."

If possible, talk with your medical team, rather than say Lupron, consider Orgovyx, faster to castration, better at sustaining castration , faster recovery of T and lower CV SE profile.

Kevin

I started with a PSA of 4.7. My biopsy returned all 14 Gleason scores at 10. Many were counted twice that. Immediately got Lupron. 2012.. today.. 2023, I am still on Lupron and it still works. I’ve had radiation twice.
So your body can tolerate the Lupron and it can tolerate the radiation. You will still be moderately active and happy. I, especially hope you have a significant other to support you. If so, I think your life will be fine, the side effects are manageable. Be ready to lose your sex drive. My story obviously has an aggressive. . My story obviously has an aggressive and invasive prostate cancer driving everything and not going away. Many people go into remission, only a few do not. Good luck to you!

I had a Gleason score of 4+4; the cancer appeared to be contained in the prostate with no obvious 'puching' of the outer membrane. I chose PBT at Mayo/Rochester. They suggested a short course of 4 months of ADT (Lupron, I think). My understanding was the reason for the ADT was to add to the possibility that injured or damaged prostate cancer cells would not have the 'food' of testosterone.
I had reduced libido, increased ED and perhaps increased emotional lows (hard to distinguish ADT vs the middle of the pandemic).
Since then my PSA has stayed about .02.

ADT certainly has benefits depending on individual diagnoses and circumstances, but I (and others, I believe) might have benefitted with more coaching about the need for muscle strengthening /maintaining exercise and maybe emotional coaching. It was certainly 'different' to have my libido hit zero. Since the ADT shot has worn off, I've had some recovery of libido and ED. Not sure about muscle loss.

Hope that helps.

Gleason grade 4+3 with cancer contained in prostate. PSA level was 8.6 for 74 year old at date of cancer diagnosis. Decipher score of 48 and PSMA pet scan confirmed no spread. Decided against four months of hormone therapy due to potential side effects both physical and mental. Decision was related to quality of life in last remaining years rather than quantity of life. Proton therapy completed nine months ago and PSA level continues to decline in line with expectations. Prior to decision, read extensively about pros and cons of hormone therapy and made decision I felt was best for me. Obviously, time will tell.

@rcooley36, I hope you saw all the helpful comments from fellow members. Did you decide to go with hormone treatments after radiation? How are you doing?