Actually "deranged" is a fairly common way of describing medical abnormalities not just the immune system.
https://khn.org/news/article/covid-autoimmune-virus-rogue-antibodies-cytokine-storm-severe-disease/
It sounds better than the immune system becomes "unhinged" and other terminology.

My personal favorite was that things were "running amok" as in violently raging, wild, or uncontrolled manner.

I'm taking Actemra currently but Naltrexone has always intrigued me as something else to try.

I'm very open minded about these things. I used to tell my rheumatologist that prednisone can't be the only option. We tried many things until Actemra finally worked for me. If and when I ever need to stop taking Actemra, I will mention Naltrexone to my rheumatologist to see how she responds.

We had a great partnership and we kept our sense of humor. My rheumatologist couldn't stop laughing when I told her that my flares were more like voodoo. I had no idea what caused the pain. I was thinking someone had a voodoo doll with my name on it!