I started every 3 weeks from October -January . Starting March 6 , I'll get it every 6 weeks, double the does. For the first week after immunotherapy, my stomach is achy, I get tired easy , not sure if that's the immunotherapy or my body has been through alot , we drive 8 hours there and 8 hours back. I'm just tired, I've been fighting a little over 3 years now. It's not been been bad though.