Dermatographism manifested itself last June after a bout of Covid (2nd time) and following on the heels of a stomach bug. Last summer I saw nearly every specialist one could possibly see because the dermatographism was followed by twitches and I was (finally) declared to be histamine intolerant and - surprise- found to be 100% in menopause. All of that said, Xolair was recommended. (After going the usual route of Zyrtec, Claritin, Allegra, and H2s.) First I was denied by my insurance, wrote a scathing response, and was then approved. The shots are delivered in rounds of 3. After round 1 I noticed a HUGE improvement. Had round 2 yesterday. The shots are administered monthly and I have no need of any other medication. Xolair is approved until November but I hope after the three rounds I don't need to continue.