I appreciate the words of support, and I am happy that so many of you have been able to take them without any severe effects. I've been on anastrozole for a year now. The side effects weren't bad at first, mostly just really bad hot flashes, but they don't bother me anymore. I have hereditary high cholesterol though, and had osteopenia at my initial DEXA scan. Haven't had intercourse with my husband since my diagnosis (too painful). I have memory loss and confusion. The pain and stiffness in my knees is pretty bad. I'm 49, but I feel like I've aged 20-30 years in the past 12 months. I have my appointment with my oncologist in a few hours though, so I will voice my concerns to him.