My main concern with all of these aromatase inhibitors is the long term effects for overall health. Research shows there are known deleterious effects of estrogen deprivation in healthy women under 50, accelerating the development of age-related diseases. According to the study, these women were not on AIs, but underwent bilateral oophorectomy. Currently age 49 and having been on anastrozole for a year, I have to wonder if it's the best long term health care decision for what I was told was a very common cancer that was caught very early.