@canfriend I am now in my 3rd cycle of taking capectabine (14 days on and 7 days off), and the only side effect I have had is a bit of constipation toward the 2nd week of the 1st cycle, but since then I have been fine. I just am very careful as to what I eat during the 14 days that I take the medication. I had the surgery prior to taking the chemo medication, and have not had radiation or any other treatment. I am supposed to take this medication for a total of 6 months (8 cycles), so not sure if I will experience any other effects in the coming weeks. I have a problem with sciatica, which has been ongoing prior to my diagnosis, and sometimes I do experience a strong tingling sensation in my legs and toes associated with that, especially while in bed, and have to put my feet on the floor for a few minutes for it to go away. It is nothing like what you are experiencing. I have autoimmune issues, including osteoarthritis, but all of that has been prior to my diagnosis and not associated with the cancer. With that my joints do ache, especially in the colder and damp weather or when I physically overdo it. My medical team, especially my oncologist, said that it is possible for one to get neuropathy in their hands/fingers, but not sure if toes would also be included. I agree with @colleenyoung that you should discuss your issues with your oncologist and chemo nurse to learn more about this. It may not be associated with the capecitabine, but rather with the radiation or other treatments you may be getting. You may also want to discuss this with the surgeon to see if he or she has any insights to offer. I will keep you in my prayers and hope you get some resolution to this soon. Best of luck to you, and please keep us posted.