Finaly, I feel like this group is taking a serious look at LDN. I've been on it at 2 mgs since mid 2019. It stopped my nonmoving pain in two nights. However, the pain when I was using my muscles continued. So I would say it isn't a panacea. However, those of us with multiple autoimmune disorders (I have Crohn's) have nothing to lose from trying it. (It healed my small intestine.) It doesn't have side effects like pred. It is very benign. The dose that most LDN users take is 4.5 mg a night. I settled at 2mg because I couldn't tell a difference between 2mg vrs. 4mg. Now I wonder if 4mg might be better. I might have even more relief from my leg pain. My search for a U.S. Dr. who knows how it works continues. It is more common in the UK.