ajh,

My sister is at month 12 from diagnosis. She was borderline resectable, but even with neoadjuvant chemo and radiation managed by Mayo Rochester (constant folfirinox chemo therapy followed by radiation to shrink tumor) the cancer spread before a Whipple could occur.

First decision is - chemotherapy or not?

She did not do things she wanted to do, mainly because there was a chance of life extending surgery. If she had not believed there was a chance of life extending surgery, she likely would have integrated some chemo approach with travel, relatives, whatever made her happy.

A decision could be made to forgo chemo and enjoy life as much as possible.

I'm trying not sound defeatist, but after spending months organizing my unmarried 65 yo sister's estate and financials as she declined, I think I would advise in depth, careful estate planning, simplification of financials including automatic payments and deposits, investment changes to better provide for children, etc. Trust, Will, DNR, Healthcare Surrogate, Durable Power of Attorney, specific instructions, user name and password listing ... coordinate everything.

Stay BUSY, enjoy life to fullest extent possible.