You need to know that there are two biopsy options. The first is MRI guided Transrectal UltraSound (TRUS) biopsy. The second is MRI guided Transperineal biopsy. TRUS which has been around for a long time involves a probe which contains the sampling needles which goes up the rectum and then goes through the rectum wall to access the prostate. The doctor will place some antibiotic gel inside the rectum and the patient must take a Cipro pill prior to the procedure. Shortly before this you must perform an enema at home. How well it is done is very important since there is some risk that some fecal matter could pass through the hole in the rectum wall resulting in an infection/sepsis. MRI guided Transperineal biopsy totally ignores the rectum route. It involves numbing the area between the anus and scrotum. The doctor then (I think) makes a very small incision and with the aid of the MRI, guides the probe directly to the MRI detected spot to take samples. Note that at least 2 Mayo doctors don't even do TRUS anymore. One person on this forum said that more areas of the prostate are accessible with the MRI guided Transperineal biopsy. It is not possible to post a webpage URL, so I will give you the titles of the articles to read as follows: Mayo Clinic Minute: Prostate biopsy technique reduces infection risk (June 13, 2022) and also Ultrasound-guided transperineal prostate biopsy (Nov 05, 2019). I will be consulting with my urologist on Feb 16 about the one spot that the MRI detected and will request a MRI guided Transperineal biopsy along with a whole lot of numbing juice!! Please be sure to connect with the rest of us regarding anything new you have learned. In my case I cancelled my TRUS appointment since they did not offer Transperineal in my area. It's your body, go with what your gut tells you. Knowledge is power.