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Long term effects AFTER withdrawing from Effexor

Depression & Anxiety | Last Active: Dec 1 11:46am | Replies (201)

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@katydid36

I'm really hoping I can get some help here. I was on Effexor for close to 30 years and my maximum dosage was only 75mg. About a year ago I went down to 37.5mg. In Dec. 2022 depression and panic came back so I told my GP that I needed some help and together we decided to wean me off Effexor and start me on Zoloft. I weaned off this very low dose for four weeks with zero withdrawal symptoms. I wasn't sure how I was feeling about Zoloft at this point because I was pretty much a wreck emotionally with my husband having one serious medical issue over the past 10 months. All this to say, after two weeks of having zero Effexor and zero withdrawal symptoms I suddenly developed nearly every symptom and they are horrible. I'm at the end of the second week of these symptoms now. I have severe panic disorder and am now paralyzed with fear. I have searched as much as I can stand for an answer to my question and I think if I can find an answer it may give me the courage to bring my doctor into it all at this point. My question is - is it possible to start feeling withdrawal weeks AFTER what I thought was a successful weaning? Thank you for reading this far.

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Replies to "I'm really hoping I can get some help here. I was on Effexor for close to..."

Welcome @katydid36, It is possible to start feeling withdrawal weeks after successfully tapering off Effexor. I moved your post to this existing discussion:
– Long term effects AFTER withdrawing from Effexor: https://connect.mayoclinic.org/discussion/long-term-effects-after-withdrawing-from-effexor/

I did this so you can connect with other members like @mehndif79 @angey @sears @ekmclean @jakedduck1 @abcxyz @texasduchess @jacqueliner and others who have experienced this delayed effect to help understand what to expect and how to manage the side effects.