Hello, I’m researching mixed connective tissue disease for my husband. I am a member of the Joint Replacement group on Mayo Clinic. My husband has been suffering for 8 yrs.with pain that has affected several parts of his body. He is currently under the care of a rheumatologist. She has tested him regularly for markers for all sorts of diseases.Back in2012 he had bi lateral TKR, 2015 he had bi lateral hip replacement, 2016 he had 3 levels of neck fused, 2017, he had carpel tunnel done on both wrists. In 2018 he had a fall that caused a subdural hematoma, which almost didn’t end well! But he survived and so did I. All along he has been suffering SEVERE SEVERE pain in both wrists. He is on medication for this and also. B/P issues. It is apparent to me that his pain is increasing in frequency and severity. Does anyone suffer from such debilitating pain caused by MCTD.? And if so, what has been your experience and does anyone have a great doctor for said disease? Thanks. Irish283@irish283