I have been taking Zetia daily for several years now. I was also taking (Pitavastatin) Livolo along with it. I have suffered leg cramps, leg twitching and pulsing while sleeping and never getting enough sleep even though I was taking 300 mgs. of Gabapentin and 400 mgs. of Magnesium Citrate nightly. I have known people who had muscle problems, sometimes life changing problems, from taking statins so I asked my doctor if I could cut back on mine (my cholesterol levels were never really high). He agreed for me to cut the Livolo down to 2 days/week. It has alleviated enough of my nightly problems so that most nights I can get 7 to 8 hours of sleep with only minor interruptions.
I wonder if eliminating statins altogether would alleviate my leg problems, but my doctor is hesitant to agree.