Hi @protonbeam, these are good questions to ask an appointment coordinator at Mayo Clinic as you explore your options. You can start your queries by calling or filling out the online form here: http://mayocl.in/1mtmR63

Here's more information about:
- Esophageal cancer care at Mayo Clinic https://www.mayoclinic.org/diseases-conditions/esophageal-cancer/care-at-mayo-clinic/mac-20356094

One of the advantages of care at Mayo Clinic is that experts in several specialties form a multidisciplinary team focused on the patient. Working as a team, doctors are able to provide comprehensive diagnosis and treatment plans that are tailored to your wife's needs. The care team may include gastroenterologists, surgeons, pathologists, oncologists, radiologists, radiation oncologists, dietitians and others as needed.

Along with @nbern, I'd like to tag a few other esophageal cancer survivors who went to Mayo Clinic to share their experiences with you, like @dtaylor75 @sepdvm @pellaw @maryhelen @survivorsuz @puprluvr @lori57216 and others.

You may also be interested in these related discussions:
- Esophageal Cancer: How do I get started with Mayo? https://connect.mayoclinic.org/discussion/get-started-with-mayo/

Protonbeam, which Mayo location would be your preference?

You are asking a really great question. It's a question you can ask of any of the major cancer centers and see what kind of answers you come up with. Second opinions are really important for cancer patients. Sometimes the treatment you are getting might be just what is always being done. Being proactive and doing your research is really great and I wish you well with your quest for answers to difficult questions.