Hi Debra, I had one failed endometrial biopsy (very small, closed cervix), then another one at Mayo (same reason, valiant effort made by the provider), then a successful one done under anesthesia. In some cases the body relaxes enough with anesthesia that they can perform the biopsy in order to get a diagnosis. That was my case, and I was diagnosed with endometrial cancer. I proceeded with a total abdominal hysterectomy (including ovaries: I was 58 and post-menopausal) and also received both radiation and chemotherapy. So my long response means to ask: how many times have they tried? I understand your concern about having a hysterectomy when you don't have a complete and/or accurate diagnosis of cancer. Let us know how you're doing, okay?