I was recently referred to the urologist after my PSA rather quickly rose to 4.63. Subsequent biopsy indicated cancer with a Gleason score of 3+4 and a PET scan showed the cancer was confined to the prostate. With this information, my urologist and I thought I was a good candidate for “active surveillance”. Then the Decipher results came back as “high risk”. To answer your question, yes this information changed my treatment. The Decipher report made clear that “active surveillance” would not be appropriate. So I plan now to go the radiation and hormone therapy route and will be meeting with the RO in the near future.