Hi @sparklegram I encourage you to do research on hormone-blocking long-term side effects. I took Arimidex for 10 years and still had a recurrence 14 years later, To answer your question no I don't recall any side effects after stopping. I was hoping that my hips and low back ache constantly would cease, but I'm sure the Neulasta played a part. I was ER PR positive both times. It's amazing how many hormones are in the food we eat. I personally wish I would not have taken the hormone blockers since they didn't stop the recurrence. Maybe, I would feel healthier now and not have to shave my fu man chu 🙂 I'm considering the Estrogen supplements to help with the Heat I still do have not hot flashes like they were but I sweat like a construction worker now.