I am 73 yo female and have been on Effexor for 22 years at 150 mgs. It is causing anxiety during winter months. I have surges and it is connected to my GI track. It makes mr ainsey I am going to start a long titrate like Sheffield Smith. Will take time to get to 75 mgs -. I went on the stuff in 2000 because of mild anxiety and it had an off label use for reducing hot flashes. I was a breast cancer patient show they would not give me any estrogen. During the inter months this stuff literally sets my "ass on fire". I think it should be taken off the market. Please share any experience strength and hope you can.